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KMID : 0614020080230010064
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Journal of Pharmaceutical Sciences (C.N.U.)
2008 Volume.23 No. 1 p.64 ~ p.69
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Screening of Vietnamese Medicinal Plants for Osteoblastic MC3T3-E1 Cell Growth
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Choi Eun-Mi
Kim Young-Ho
Lee Eun-Joo
Cuong Nguyen-Manh
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Abstract
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Many plant-derived substances have estrogenic activities. Due to their ability to bind the estrogen receptor, these compounds have the potential to counteract the deleterious effects of estrogen deficiency on bone. In this study, traditional Vietnamese medicinal plants were screened for their stimulatory effects on the growth of osteoblastic MC3T3-E1 cells. As a result of screening, the extracts of Strobilanthes cusia(142%), Celatrus sp.(123%), Camelia chinensis(116%) and Trichosanthes kirilowii(117%) had significantly high viability compared to control at 30 ug/ml (P < 0.05). The extracts of Bousingonia mekongense(123%) and Goniothalamus vietnamensis(116%) also significantly stimulated the growth of MC3T3-E1 cells at 3 and 0.3 ug/ml, respectively (P < 0.05). These results suggest that these Vietnamese plants may play important physiological roles in the prevention of postmenopausal osteoporosis.
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KEYWORD
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Vietnamese plants, Strobilanthes cusia, osteoblastic MC3T3-E1 cells
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